depmap

DepMap — Cancer Dependency Map Overview The Cancer Dependency Map (DepMap) project, run by the Broad Institute, systematically characterizes genetic dependencies across hundreds of cancer cell lines using genome-wide CRISPR knockout screens (DepMap CRISPR), RNA interference (RNAi), and compound sensitivity assays (PRISM). DepMap data is essential for: Identifying which genes are essential for specific cancer types Finding cancer-selective dependencies (therapeutic targets) Validating oncology drug targets Discovering synthetic lethal interactions Key resources: DepMap Portal: https://depmap.org/portal/ DepMap data downloads: https://depmap.org/portal/download/all/ Python package: depmap (or access via API/downloads) API: https://depmap.org/portal/api/ When to Use This Skill Use DepMap when: Show more