Conservation Scores & TFBS Lookup (UCSC) This skill provides access to evolutionary constraint scores and conserved elements from the UCSC Genome Browser. It retrieves scores from the PHAST package — specifically phastCons (identifying functional blocks) and phyloP (measuring individual site constraint) — calculated from multiple alignments. Use this skill to determine if a non-coding variant hits a site that hasn't changed since a common ancestor (which is a strong signal for pathogenicity) or to find conservation peaks across a regulatory element. Prerequisites Show more Installs 436 Repository google-deepmind…e-skills GitHub Stars 1.5K First Seen May 19, 2026
ucsc-conservation-and-tfbs
安装
npx skills add https://github.com/google-deepmind/science-skills --skill ucsc-conservation-and-tfbs